I have the
Kata DR-467i. It fits my T1i with 24-105mm attached, plus four other lenses (smaller primes, UWA, and my 55-250mm), al in the lower compartment. It also fits my 16" Dell laptop (and will easily fit a 15" MacBook Pro). The upper compartment can hold another lens (like a 70-200), but I use it for all my filters, batteries, cables, remotes, etc, etc. It also has some smaller front pockets for such stuff. It has a pull-out holder for a tripod as well. Pretty easy to carry on one shoulder or two. It has a strap across the back for slipping over a rolling suitcase handle.
Note: When it's loaded, it's heavy. And yours will be worse with more lenses and the big 70-200. I load mine up for travel to wherever I'm going and then I use a smaller sling style bag for day-to-day walking around. I also just ordered a smaller messenger style bag for such use.