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Of course. I have 4 mining rigs at home, now, and 1 desktop. The mining rigs mine 24/7, and the desktop rig mines whern I am not using it, on its single GPU, a 1080ti.
Of course, if your desktop does not have a relatively modern, discrete GPU, you won't be able to mine much, and will likely use more electricity than you earn on mining. The profitability calculator I linked above will show you how much a GPU can make in mining.
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2015 Black Sapphire Metallic 6MT M4
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